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KMID : 0360319940260050793
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Journal of Korean Cancer Research Association
1994 Volume.26 No. 5 p.793 ~ p.800
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Expression of p53 in the Benign and Malignant Tumor of Prostate
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Abstract
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Immunohistochemical expression of the p53 was studied in 20 cases of benign prostatic hypertrophy(BPH) and 56 prostatic adenocarcinomas using a monoclonal p53-specific DO7 antibody (Novocastra, U.K.) on formaline-fixed paraffin-embedded tissue
sections.
Proliferative activity was determined by immunohistochemical detection of proliferative cell nuclear antigen (PCNA) using a monoclonal PC10 antibody (Novocastra, U.K.) Eleven of 56 prostatic carcinomas(19.6%) showed strong immunostaining for p53
in
more
than 20% of tumor cells and 15(28.6%) had focal(≤20%) immunoreactivity. The glandular epithelium adjacent to carcinomas showed features of prostatic intraepithelial neoplasia which was stained positively for p53 in 25%, but all cases of BPH
showed
no
staining. High grade carcinomas(Gleason's combined score≥7) were associated with more intense and extensive p53 staining. High PCNA staining(higher than 50%)showed more p53 immunoreactivity(81.8%) than those cases with lower PCNA staining(40%).
These findings indicate that altered expression of p53 protein occurs in a prostate cancer and is associated with increased proliferative activity and appears to play a role in the develpment of highly malignant prostatic carcinomas.
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KEYWORD
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